MARC, A NOVEL MODULAR CHIMERIC ANTIGEN RECEPTOR, IMPROVES T CELL-BASED CANCER IMMUNOTHERAPIES BY PREVENTING EARLY T CELL EXHAUSTION AND ENHANCING PERSISTENCE

Background Chimeric antigen receptor T cell (CAR-T)-based immunotherapies have reshaped the therapeutic landscape of cancer treatment, in particular for patients afflicted with leukemia.However, defects in CAR behaviors and clinical complications have hindered their widespread application across diverse cancer types.Chief among these defects is hig

We deal with a generalization of the risk model with stochastic premiums where dividends are paid according to a constant dividend strategy and consider heuristic approximations for the ruin probability.To be more precise, we construct five- CHARCOAL FACIAL DETOX SOAP and three-moment analogues to the De Vylder approximation.To this end, we obtain

For copyright protection of diffusion-weighted imaging (DWI) images, traditional robust watermarking Analgesics techniques result in irreversible distortions, while reversible watermarking methods exhibit poor robustness.We propose a two-stage lossless watermarking algorithm based on a Transformer network to solve this problem.The first stage of th